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How synergy is formally established Pharmacology has settled methods for this, and they share a requirement: you must characterise the dose-response of each agent alone, then of the combination across a matrix of ratios
Complexity increases with additional stack components, requiring careful attention to interactions, timing, and individual response assessment
These adverse events can be serious or even life-threatening
Regardless, this is a far cry from the effects on skeletal muscle that have been reported by some independent researchers
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