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Effects of intensive control of glycemia on clinical kidney outcomes in type 2 diabetes patients compared with standard control: a meta-analysis

Epub 2022 Feb 25

Results indicate that DA-JC1 reduces neuroinflammation by inhibiting the proliferation of astrocytes and microglia in the substantia nigra, and mitigates the damage of toxic substances MPTP to midbrain dopaminergic neurons and fibers by promoting the expression of BDNF, phosphorylation of Akt in the PI3K/Akt signaling pathway, downregulating the pro-apoptotic protein Bax, and upregulating the anti-apoptotic protein Bcl2 (109, 110)

Glucagon A hormone that signals the liver to release stored glucose and promotes fat breakdown for energy