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The high prevalence of GLP-1 use among patients with advanced MASH and comorbidities such as diabetes and obesity also highlights the importance of considering GLP-1 as part of combination therapies in the development of new treatment strategies and clinical trial designs for this population, Gao said
Who should avoid: Patients with uncontrolled hypertension Those with significant cardiovascular disease (relative caution) Patients taking other medications that affect heart rate or blood pressure Monitoring: Blood pressure and heart rate should be monitored during treatment, particularly during titration
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When monoglutamate folates are taken up into cells, particularly in the liver and kidney where they can be stored (but also in other cells), they are polyglutamated through the action of the enzyme folylpolyglutamate synthase
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