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While these features are associated with a LoF phenotype, other studies suggest that both GIPR agonists and antagonists may provide benefits to T2D and obesity (Yang et al., 2022), indicating a complex mechanism of GIPR action within the processes of blood glucose and weight regulation
Harrow B, Fagnani F, Nevoret C et al (2022) Patterns of Use and Clinical Outcomes with Long-Acting Somatostatin Analogues for Neuroendocrine Tumors: A Nationwide French Retrospective Cohort Study in the Real-Life Setting
Strictly adhering to the prescribed titration schedule is criticalpatients should not increase doses more rapidly than recommended, even if tolerating the current dose well, as this increases the risk of prolonged side effects
95,96 DCM appears to progress through an initial subclinical phase characterized by subtle structural and functional abnormalities (e.g., impaired diastolic relaxation), followed by severe diastolic heart failure with preserved ejection fraction (HFpEF), and ultimately progresses to systolic dysfunction presenting as heart failure with reduced ejection fraction
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