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GLP-1RAs have been proven to reduce the risk of major adverse cardiovascular events (MACE) occurrence, including death from cardiovascular causes, non-fatal myocardial infarction and non-fatal stroke, as well as all-cause mortality in T2DM and patients with obesity ( The glucocorticoid receptors are present in GLP-1-producing cells, and their activation diminishes the secretory responsiveness of these cells ( 4.1 Efficacy of GLP-1 receptor agonist therapy in SID Considering their beneficial effects on body weight, effective glycemic control, and low risk of hypoglycaemia, GLP-1 RAs may be suitable therapeutic options for SID and SIH, either as adjunctive therapy or as primary treatment
PMID 13845950
Eli Lilly announced the clinical trial results in a news release Thursday, though they havent been peer-reviewed or published in a medical journal
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