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Dysregulation of FoxO proteins, including FoxO4, is linked to metabolic diseases such as insulin resistance and type 2 diabetes
Peroxisomal lipid synthesis regulates inflammation by sustaining neutrophil membrane phospholipid composition and viability
In particular, fatigue with post-exertional malaise, cognitive impairment characterized by deficits in executive functions, concentration and memory and depressed mood [88] are the main features of neuropsychiatric long COVID syndrome [31], with fatigue being the most common and debilitating [99]
The brainstem, which has been implicated to be affected in PASC, explaining the broad spectrum of symptoms, particularly pain and autonomic symptoms [156], has been found to show glucose hypometabolism in patients (among other regions) [47, 53, 89]
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