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FDA may issue no objection (the company may market, though this is not approval) or object (e.g., safety concerns or incomplete data)

This could diminish the unique advantage retatrutide holds over dual-agonists like tirzepatide

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It is estimated that cigarettes contain about 5000 toxic substances such as nicotine, tar, carbon monoxide, volatile organic compounds (VOCs), polyaromatic hydrocarbons (PAHs) and tobacco-specific nitrosamines (TSNAs) [64]