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That prevalence alone makes any compound with pre-clinical gastroprotective properties worth examining in equine contexts
Most IAPs have a RING domain at their C-terminus that is required for ubiquitination of their substrates as well as auto-ubiquitination of some members including c-IAP1, c-IAP2 and X-linked inhibitor of apoptosis (XIAP) 61,62
The components are put into an IV bottle and infused intravenously over 20 minutes
It is still a useful benchmark: compare it against the measurement error of reading 2.5 units on a U-100 syringe, where a single unit misread at 10 mg/mL is a 40% error on a 0.25 mg step
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