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Both stimulate fibroblast proliferation and extracellular matrix production
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The class is not uniformly effective, even topically: a controlled irradiated-rat study found no benefit of topical GHK-Cu on flap ischaemia, vessel number/area or VEGF versus control a clean negative that tempers enthusiasm for the whole class [11]
Who should avoid GHK-CU Wilson's disease or copper metabolism disorders Active malignancies (until more research exists) Pregnancy and breastfeeding Known copper sensitivity or allergy Those unable to maintain sterile injection technique When uncertain, consult a healthcare provider familiar with peptide research
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