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While this provides body composition benefits including fat loss and muscle growth, it also affects glucose metabolism (often elevating blood sugar), increases IGF-1 (with implications for cell proliferation), and costs significantly more than AOD-9604

Separately supported: the FDA NDA 215866 tirzepatide Clinical Pharmacology Review reports that Japanese subjects "appear to be more sensitive to HR increases than non-Japanese subjects under similar tirzepatide exposures" a genuine matched-exposure sensitivity difference

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Constant tiredness, foggy thinking, or numb hands might seem minor, but should not be ignored