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Gilbert MP, Pratley RE (2020) GLP-1 analogs and DPP-4 inhibitors in type 2 diabetes therapy: review of Head-to-head clinical trials
Both Retatrutide and Tirzepatide activate GLP-1 and GIP receptors, so combining them would produce overlapping receptor stimulation without additive benefit, while likely increasing side effect severity
Lancet 2021;398:58398.ArticlePubMed 55
Treatment decisions when prescribing SGLT2is and/or GLP-1 RAs in adults with CKD and T2D who have overweight/obesity are strongly influenced by tolerability and safety (88%)
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