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All existing evidence is from cell cultures and rodents, and the compound is classified as research-use-only

Laboratory Tests: During the initial treatment of patients with pernicious anemia, serum potassium must be observed closely the first 48 hours and potassium replaced if necessary

Those with pre-existing cardiac conditions or on medications affecting potassium levels may require closer monitoring

Diet-induced obese animals exhibit indices of altered central monoaminergic neurotransmission, including reduced hypothalamic 1 adrenoceptor binding, enhanced electrophysiological responsiveness to norepinephrine application, decreased basal hypothalamic serotonin and dopamine levels, and reduced mesolimbic dopamine activity