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The administration of Lycium barbarum polysaccharide (LBP, 25, 50, and 100 mg/kg) to rats for three consecutive weeks intragastrically was found to effectively inhibit the excessive activation of NR2B in the prefrontal cortex of rats, reduce the expression of calmodulin kinase II (CaMKII), a crucial downstream signaling molecule of NMDAR, and alleviate depressive-like behaviors in rats with PTSD (Chu, 2019)
Pi-Sunyer et al, 2015)
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