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Conclusion NPT1, NPT4, ABCG2 expressed on the apical membrane and OAT1, OAT3 expressed on the basolateral membrane have been confirmed to contribute to the secretory transport of urate from proximal tubular epithelial cells into the tubule lumen (Wen et al., 2020)
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Tirzepatide treatment was administered at three final doses (5, 10, 15 mg per week), with treatment initiated at 2.5 mg and the dose escalated every 4 weeks
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