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At high doses (over 3 g), nausea, stomach cramps, diarrhea, and a "fishy body odor" (trimethylamine accumulation) can occur
If symptoms persist despite these measures, patients should discuss with their provider whether maintaining the current tirzepatide dose longer before escalating might be appropriate
doi: 10.1016/j.exger.2018.11.016 55 DaviesM
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