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In the CHARISMA trial, patients with established atherosclerotic cardiovascular disease (symptomatic) or multiple risk factors for atherosclerotic disease (asymptomatic), but without active acute coronary syndrome, were randomly assigned to receive either clopidogrel plus aspirin or placebo plus aspirin
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To push its GLP-1 agonist past the clinic, the company raised $287 million in a series D1 funding round in January
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MI operations were conducted on 810 week-old male Pcsk5 ECKO and Pcsk5 WT littermate mice post-tamoxifen administration (Fig
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