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Oxidation of xenobiotics is non-specifically catalysed by a number of enzymes located in the microsomes

Glutathione is necessary to help protect our cells from damage due to oxidative stress, mercury and other toxic metals, alcohol, persistent organic pollutants, and much more

We surmise that oxidative stress tolerance in the TA would be increased through improved maintenance of redox homeostasis compared to the WT and EV (Figures 27 and Supplementary Figure S3)

In the high-concentration Pi-induced VSMC calcification model, overexpression of PDK4 located in the mitochondria and cytoplasm increased the phosphorylation level of SMAD1/5/8 and promoted its nuclear translocation, enhancing the activity of Runx2 and ALP promoters downstream of Bone Morphogenetic Protein 2 (BMP2) through the BMP2/SMAD pathway, inducing VSMC osteogenesis