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Furthermore, multiple studies have demonstrated that collagen peptides can inhibit the expression of pro-inflammatory factors, such as tumor necrosis factor-alpha (TNF-), interleukin-1 beta (IL-1), IL-6, IL-8, inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2), in fibroblasts and keratinocytes, thereby mitigating inflammatory responses [32, 33]

In contrast, isoprenaline elevated force of contraction in left atrial preparations after rolipram from WT mice (Fig

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