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The dose of BAY11-7082 was chosen based on our preliminary results of dose response, which showed that 10 M BAY11-7082 significantly increased the number of surviving SGNs after cisplatin damage in vitro (Supplementary Figure 2)
The trial product estimand addressed the average treatment effect in all randomly assigned participants, assuming that the drug or placebo was taken as intended (participants on treatment)
Similarly, certain medications including corticosteroids or antipsychotics can counteract weight loss efforts
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