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In a prespecified extension of TRIUMPH-1 for patients with BMI 35, average weight loss reached 30.3% at 104 weeks compared to 28.3% at the 80-week primary endpoint
In the U.S., MOUNJARO (tirzepatide) is indicated as an adjunct to diet and exercise for glycemic control in adults and pediatric patients aged 10 years and older with insufficiently controlled type 2 diabetes mellitus as monotherapy when metformin is not appropriate, or in addition to other antidiabetic agents.[4] MOUNJARO does not carry a U.S
This elevation of NPY has been associated with a significant reduction in BMD and bone microstructure, which suggests that NPY may contribute to the negative effects of glucocorticoids on bone health [79]
