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In addition, a Phase 1/2 multicenter study is ongoing to further assess the safety, tolerability, efficacy, pharmacokinetics (PK), and pharmacodynamics (PD) of SLN124 in PV patients [43]

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Abdominal bloating and/or flatulence Appetite loss Diarrhea or constipation Fever (usually low grade but may worsen as the condition progresses) Nausea and vomiting (occurs in 75% of patients) Diagnosis and Treatment To confirm a diagnosis, an emergency room physician will do a physical exam (apply gentle pressure on your abdomen to assess your pain), and carry out the necessary tests (e.g., blood, urine, and imaging tests)