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453,454,455,456,457,458 Autophagy also enhances osteoclastogenesis through an overactive autophagy-lysosomal system, facilitating cartilage erosion and bone destruction

doi: 10.1007/BF00186626 50 KrysiakROkopienB

The extrinsic pathway is primarily induced via suppression of system X c [33], which is a cellular membrane amino acid transporter responsible for exporting glutamate and importing cystine, thereby regulating glutathione (GSH) biosynthesis