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This pattern aligns with B12 pharmacokinetics: serum levels peak 8-12 hours post-injection, tissue saturation occurs over 48-72 hours (Andrs et al., Journal of Blood Medicine , 2018)
Out of the total participants, 142 individuals experienced at least one MACE-4 event, with 109 from the high cardiovascular risk trial and 33 from the six trials with lower cardiovascular risk
Our results are in harmony with other studies that reported the capability of sitagliptin to improve kidney function and attenuate the histopathological changes in different experimental models such as diabetic nephropathy 114 , ischemiareperfusion injury 34 , gentamicin nephrotoxicity 115 , and cisplatin-induced nephrotoxicity in mice 116
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