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5-FU administration for 24 h can increase the expression level of bound TS in HCT116 and HT29 CRC cells and inhibit the expression of p53, thereby tolerating 5-FU ( In BC, 5-FU combined with QUE further promoted the apoptosis of MCF-7 cells by increasing the expression of Bax, Caspase-9, and p53 genes and decreasing the expression of bcl-2 genes, indicating that QUE could enhance the sensitivity of 5-FU to BC ( In conclusion, the present study suggests that QUE sensitizes CRC and BC cells to 5-FU by regulating the expression of apoptotic proteins ( Table 1 )
doi: 10.3389/fnins.2025.1671955 Received 24 July 2025 Revised 10 December 2025 Accepted 16 December 2025 Published 13 January 2026 Volume 19 - 2025 Edited by Fangchen Gong, Shanghai Jiao Tong University, China Reviewed by Al-Shaimaa Faissal Ahmed, Minia University, Egypt John Sieh Dumbuya, Affiliated Hospital of Guangdong Medical University, China Updates Copyright 2026 Li, Wang, Ma, Peng, Wang, Wang, Li and Wang
Just like the story of Goldilocks and the Three Bears only one bowl of porridge is just right the extremes of too hot (too high IGF-1) and too cold (too low) are definitely not preferable
Onset: Days 1-3 Sleep disruption, when it occurs, appears within the first 1-3 days of starting BPC-157
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