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A larger person may process the same milligram dose differently than a smaller person, potentially experiencing less intense appetite suppression at the same dose
Several case reports have documented individual patients with lipedema who experienced symptomatic improvement and some reduction in limb circumference while taking incretin-based medications, particularly semaglutide
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or they might display enhanced -arrestin recruitment, higher degradation rates and/or defective ligand binding ability (Tao and Conn, 2014)
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