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A preclinical study showed that combining the MCT1 inhibitor AZD3965 with anti-PD-1 therapy reduces lactate release into the TME, enhancing tumor immune efficacy (48)

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[Genetic polymorphism of glutathione-s-transferases theta1 and mu1 in lung oncology [PMID: 18416133] Laboratory literature summary: [Genetic polymorphism of glutathione-s-transferases theta1 and mu1 in lung oncology research models]

Nonetheless, optimal doses, treatment schedules and testing efficacy of other antioxidants in preventing THC-induced abnormalities remain to be established