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Their exact function in human hair biology remains under investigation, but the presence of these receptors raises the possibility that GLP-1 medications might directly affect hair follicle cycling, independent of weight loss or nutritional status

Possible side effects of IGF-1 DES can include [1, 16]: Impaired glucose metabolism and hypoglycemia Fatigue Changes in sexual function Swelling of soft tissues Hyperandrogenism Muscle and joint pain Fluid retention Gynecomastia Orthostatic hypotension One of the more serious side effects of prolonged IGF-1 DES administration is acromegalic cardiomyopathy (enlargement and weakening of the heart)

Foundayo (orforglipron) is also not currently recommended because there are no studies in breastfeeding women, and the drug was found in the milk of lactating animals

doi:10.1007/s13311-013-0238-x