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Supplemental Materials Acknowledgements The authors gratefully acknowledge the support of the National Institute of Dental and Craniofacial Research (NIDCR), and the National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health, under award numbers UG3DE027695 and UH3 DE002212 to DSWB, CEO, and LAD, T32 ES007026 to JAM, and F31 DE029658 to LRP

In the Attain-1 trial, focused on adults with obesity without diabetes, participants achieved up to 12% body weight loss

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Interpretability evidence that connects digital biomarker features with known disease mechanisms and clinically meaningful symptoms is particularly important when digital biomarkers are intended to support key clinical trial endpoints or treatment decisions