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de novo methionine synthesis whereas cytosolic isoforms are most probably involved in the regeneration of Met from homocysteine ( The CGS is a pyridoxal 5-phosphate (PLP)-containing homo-tetramer that uses o -phosphohomoserine (derived from aspartate) and cysteine as substrates for cystathionine biosynthesis ( Nicotiana tabacum transgenic plants highlighted both a strongly altered development and an impaired Met metabolism

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levels above 400 pg/mL suggest high probability of acute decompensated heart failure (per ACC/AHA guidelines)

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