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Postbariatric hypoglycemia: symptom patterns and associated risk factors in the longitudinal assessment of bariatric surgery study

The US Food and Drug Administration has recently warned its citizens against using such so-called "gray-market" GLP-1s

At this time, peptide therapy mimicking native hormones came into the arena

What they found: Melanotan II is 100 to 1000 more potent than native -MSH in melanocyte assays Cyclization preserves the active conformation longer than linear -MSH Activates all four functional melanocortin receptors (MC1R, MC3R, MC4R, MC5R) In vivo: visible pigmentation of lizard skin within hours, not days as with -MSH Why it matters: This is the foundational publication of Melanotan II