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The full titration schedule typically spans 16 weeks, with dose increases every four weeks: 0.25 mg (weeks 14), 0.5 mg (weeks 58), 1.0 mg (weeks 912), 1.7 mg (weeks 1316), and 2.4 mg (week 17 onward)
Rare but serious risks include pancreatitis, gallbladder disease, and thyroid tumors (seen in animal studies, not confirmed in humans but flagged by the FDA)
Although I 2 is commonly used for assessment of heterogeneity, it is not a perfect measure and its value depends on the precision and size of the included studies
Mediators Inflammation (2005) 59(3):3217
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