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For example, under conditions of OGD, the local concentration of lactate increases, which triggers astrocyte responses by upregulating N-Myc downstream-regulated gene 2 (NDRG2) to alleviate the inflammatory state [136]
In randomized clinical trials in adults for weight reduction, cholelithiasis was reported by 1.6% of WEGOVY-treated patients and 0.7% of placebo-treated patients
Overall, both retatrutide and semaglutide are considered safe
Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used for chronic weight management, along with a reduced calorie diet and increased physical activity, for people with an initial body mass index (BMI) of: 30 kg/m2 or greater (obesity) or 27 kg/m2 or greater (overweight) in the presence of at least one weight-related comorbid condition (e.g., hypertension, type 2 diabetes mellitus, or dyslipidemia)
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