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This protection is likely due to increased growth of new neurons in the hippocampus, improved signaling of brain-derived neurotrophic factor (BDNF), better synaptic function, and reduced brain inflammation (Nichol et al., 2008)

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Differential effects of intra-ventral tegmental area ghrelin and glucagon-like peptide-1 on the stimulatory action of d-amphetamine and cocaine-induced ethanol intake in male Sprague Dawley rats

You must insert a minimum of six inches into your rectum, any less and it wont work