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Researchers consulting this stream should attend to the distinction between cell-line telomerase upregulation and in vivo organism-level telomere maintenance, since the translation between the two is not straightforward

Here, the design was set according to exposure (UNTR or DMSO), other settings were kept to their default parameters, except for minimum count, which was set to an average read count of one across all samples

Fifth, cost-effectiveness analyses are critical given the high price of current GLP-1 RAs and the large potential treatment population: preliminary health-economic models suggest acceptable cost-effectiveness ratios in high-fibrosis patients with comorbid type 2 diabetes and cardiovascular disease, but robust data in broader MASLD populations are lacking

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