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Despite producing more weight loss, tirzepatide had lower rates of treatment discontinuation due to gastrointestinal adverse events (2.7% vs 5.6% for semaglutide)

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dose escalation protocols minimise these effects Injection site reactions : erythema, pruritus, or mild discomfort at subcutaneous injection sites Serious but less common risks include: Pancreatitis : patients should be counselled to seek immediate medical attention if experiencing severe, persistent abdominal pain radiating to the back