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it is mainly due to malabsorptive syndromes (i.e., previous GI surgery, cholestatic liver disease with low bile concentration in the intestine) and clinically presents with altered immune function, retinopathy, peripheral neuropathy, ataxia, and hemolysis ( There is no clear evidence that vitamin E supplementation has a beneficial effect in reducing cancer incidence ( Also, a possible association between dietary vitamin E and increased immunotherapy efficacy has been recently reported, even though in preclinical models ( 3.4 Vitamin K Vitamin K is a fat-soluble vitamin that plays fundamental roles linked to the coagulation pathway and the activity of several protein enzymes

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