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10.1161/ATVBAHA.117.309228 Arterioscler Thromb Vasc Biol

As we age, the glutathione synthetic rate and concentration within the body gradually decrease, and a supplement of an ample amount of glutathione is required

This work was supported in part by the National Institute of Diabetes and Digestive and Kidney Diseases Grants [R01 DK 070195], [R01 DK102142], and [R01 DK125465], the National Institute of General Medicine Grants [P20 GM103549] and [P30 GM118247]

50 Similarly, upregulation of thymidylate synthase (TYMS), a target of 5-fluorouracil (5-FU), contributes to resistance in colorectal cancer by augmenting DNA repair pathways