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Until Phase II and III results emerge with proper endpoints (mucosal healing rates, histologic remission, patient-reported outcomes), the evidence base will remain preclinical
What this data doesn't tell us: whether NNMT suppression sustained beyond 12 weeks alters NAD+ metabolism in ways that affect mitochondrial function, whether methylation pathway compensation occurs over longer timescales, or whether adipose tissue remodeling continues linearly or plateaus
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