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However, individuals with rare genetic conditions like Lebers hereditary optic neuropathy or those with known severe hypersensitivities to cobalt should avoid these shots

At the concentrations typically found in cosmetic products, systemic absorption through intact skin is considered minimal, and copper toxicity from topical use has not been reported in the published literature

One older study from 2002 found that an emulsion containing 10% Argireline reduced wrinkle depth in women volunteers up to 30% after 30 days of treatment