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The primary concern involves cardiovascular effects, as phentermine can increase heart rate and blood pressure while semaglutide may affect heart rate variability through vagal mechanisms

Wegovy and other GLP-1 receptor agonists have also been linked to an increased risk of acute pancreatitis, gallbladder problems, acute kidney injury, low blood sugar, diabetic retinopathy complications, increased heart rate, and suicidal thoughts

So whichever one youre leaning toward, know that success doesnt come from the injection alone