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Using fibroblasts induced to senesce by ionizing radiation, we further observed that p53 is phosphorylated on Serine 46 and that removing FOXO4 could trigger a clean cell death response, known as apoptosis (de Keizer&Campisi, Cancer Res (2011) 71 (18_Supplement): C35.)
A 2024 orthopaedic evidence review concluded that, beyond a 12-participant intra-articular knee osteoarthritis pilot, there are no robust human musculoskeletal efficacy trials for BPC-157 [6]
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