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After initial appetite suppression, metabolic efficiency increases and the body's weight-regulatory set point gradually resets, slowing fat loss even if you remain in caloric deficit

However, current evidence suggests that with proper management of reflux symptoms, many patients can safely use semaglutide over the long term

Before reaching the target dose, a typical dosing schedule may look like the following: Month 1: 0.25 mg once weekly for the first month Month 2: 0.5 mg once weekly for the second month Month 3: 1 mg once weekly for the third month Month 4: 1.7 mg once weekly for the fourth month Target maintenance dose: 2.4 mg once weekly Depending on whether or not there are any experienced side-effects may change the dosing schedule for some individuals

Diabetologia 67 , 528546 (2024)