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4,12 End-of-dose failure and the "wearing off" phenomenon: In elderly persons, 30% of hospital admissions may be linked to drug-related problems, and falls leading to hospitalizations are especially likely in patients with PD, particularly those experiencing "wearing off," a loss of benefit from a dose of L-dopa that typically occurs after a few hours
meta-analysis: OR = 0.90, 95% CI [0.741.09]), and autism (FinnGen: OR = 0.42, 95% CI [0.320.54]
USA 109 , E524E532 (2012)
The abdomen, thighs, and upper arm are all appropriate sites, and rotating between them prevents tissue irritation and bruising that can increase discomfort over time
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