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The peptide slowed the age-related decline of estrous function and reduced chromosome aberrations in bone-marrow cells but, critically, it did not increase mean lifespan in that particular experiment (it modestly raised the lifespan of the last 10% of survivors and the maximum lifespan, without shifting the mean)

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We also performed time to event analysis using Cox proportional-hazards regression model to estimate the hazard ratio (HR) and 95% confidence intervals (CI) for all-cause mortality and cardiovascular composite event outcome for GLP1-RA group compared to DDP4i group

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