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Wong et al., 2021)
The oxidative metabolites of estrogen, especially catechol estrogens, mediated by CYP1A1 and CYP1B1, are then oxidized by a single electron to form reactive semiquinone intermediates, which can directly covalently bind to DNA and eventually lead to DNA damage [38]
This is not a compound that modulates a receptor or hormone pathway it triggers a biological process (apoptosis) that unfolds over days to weeks
Designed to penetrate the blood-brain barrier
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