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In lupus-prone mice and SLE patients, GLS2 expression is reduced in CD4 + T cells, and GLS2 reduces ROS levels and promotes the ability of CD4 + T cells to produce IL-2 by demethylating the IL-2 gene (64)
The TFAP2A/NEL3 axis has also been found to promote M2 polarisation through Gln metabolism, thus providing a theoretical basis for immunotherapy targeting cancer TMEs [119]
Very often it's coming from the covering of your brain, which is called the dura
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