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Strawn JR, DAlessio DA, Keck PE, Seeley RJ
Endothelial dysfunction is characterized by reduced nitric oxide (NO) synthesis and/or bioavailability within peri-endothelial environment, where NO is responsible for maintenance of vascular tissue integrity 3
This mutation also increased expression of the protease in mammalian cells, restoring it to levels near that of wild-type BoNT/X protease (Fig
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