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GLP-1 receptor agonists like semaglutide (Wegovy, Ozempic) and liraglutide (Saxenda), as well as dual GIP/GLP-1 receptor agonists like tirzepatide (Zepbound, Mounjaro), are not automatically disqualifying medications

Common Side Effects Reported Across Phase 2 trials, participants experienced dose-dependent GI symptoms that are characteristic of GLP-1 receptor agonists: Nausea most frequent, especially during dose escalation Vomiting typically mild to moderate, subsiding with continued use Diarrhea and constipation fluctuating depending on individual tolerance Abdominal discomfort transient and often improved over time Dose-Response Relationship At lower doses (14 mg weekly), side effects were generally mild and manageable, though some participants still reported early GI symptoms

[1] [7] When used with insulin or sulfonylureas, dose adjustments may be needed to prevent hypoglycemia

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