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481,482 (4) A fourth targeted drug approach is the activation of PPAR- in mature adipocytes that then induces altered expression of several genes (increased GLUT4 and adiponectin expression, along with decreased TNF-, IL-6 and leptin expression) involved in the insulin signaling cascade, thereby improving insulin sensitivity
As of April 1, 2026, neither drug is on the shortage list or the 503B bulks list
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