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Phase 2 trial data showed retatrutide producing up to 24.2 percent body weight loss at 48 weeks, compared to approximately 22.5 percent for tirzepatide at 72 weeks in the SURMOUNT-1 trial
Ozempic is a medication containing semaglutide, a synthetic analog of GLP-1 specifically designed to enhance and extend these beneficial effects
The key difference is mechanism: semaglutide activates GLP-1 receptors only, while tirzepatide activates both GLP-1 and GIP receptors, a dual-action approach that appears to amplify appetite suppression and fat metabolism
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doi: 10.1016/j.scienta.2020.109554 37 LiuH.ZhouX.DongN.LiuX.ZhangH.ZhangZ
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